Effects of mineral trioxide aggregate and formocresol on vital pulp after pulpotomy of primary molars: an in vivo study. 029–14). Each envelope was unsealed after the signature of the informed consent and immediately before the implementation of the first procedure on the right tooth. Formaldehyde. Formocresol pulpotomy technique When Buckley's formulation was introduced in 1904, it was used for the treatment of non-\dtal permanent teeth. As there is little consensus on how internal root resorption and pulp canal obliteration affect the outcome, the findings are listed in Table 2. Elliott RD, Roberts MW, Burkes J, Phillips C. Evaluation of the carbon dioxide laser on vital human primary pulp tissue. Cleaton-Jones P, Duggal M, Parak M, William S, Setze S. Ferric sulphate and formocresol pulpotomies in baboon primary molars: Histological responses. 2019; 37(4): 327. An envelope was for each block of two contralateral teeth (one pair). Journal of Clinical Pediatric Dentistry. Pinkerton LE, Hein MJ, Stayner LT. Mortality among a cohort of garment workers exposed to formaldehyde: An update. Nowadays, there are many concerns about the safety of formocresol due to the harmful effects of formaldehyde that led to the change towards safer … A history of spontaneous pain, missing restorations, recurrent caries, mobility and percussion sensitivity, parulis … J Lab Clin Med 1923;9:15. International Programme on Chemical Safety. Zanini M, Sautier J, Berdal A, Simon S. BiodentineTM induces immortalized murine pulp cell differentiation into odontoblast–like cells and stimulates biomineralization. Preoperative periapical radiographs were used as a baseline for comparisons in different follow–ups and to assess the periapical area. Formocresol and glutaraldehyde pulpotomies in primary teeth. BioMed Research International. 2017;20:237–40. Furthermore, this high success rate of formocresol is not in agreement with the results of other studies [34, 35]; because those studies had smaller sample sizes. The pulpotomy procedure involves covering pulp stumps with a pulp-capping agent to promote healing … A sharp sterile spoon excavator or a slow–speed round carbide bur (no. A systematic literature review Med Oral Patol Oral Cir Bucal. Pediatr Dent 1990;12:303-7. Garcia-Godoy F. A comparison between zinc oxide-eugenol and polycarboxylate cements on formocresol pulpotomies. Oral Surg Oral Med Oral Pathol 1993;76:346-50. The importance of pulp vitality preservation can never be overstated. Available from: http://www.epa.gov/iris/subst/0030.htm [Last accessed on 2007 Nov 12]. J Indian Soc Pedod Prev Dent 2005;23:13-6. 18. et al. The study was conducted on 33 primary teeth of three mongrel dogs between the ages of one to three months. Pediatr Dent. Thus, future clinical research is required to utilize BiodentineTM as a substitute to formocresol in primary teeth pulpotomy. Cytogenetic analysis of lymphocytes from rats following formaldehyde inhalation. Athanassiadis B, George GA, Abbott PV, Wash LJ. IARC, WHO. A review of the effects of formaldehyde release from endodontic materials. Formocresol has subsequently become a popular pulpotomy medicament for primary teeth. Scand J Dent Res 1976;84:345-7. A comparative study and evaluation of formocresol and glutaraldehyde pulpotomies on primary molars PhD Thesis. J Endod 1980;6:728-30. http://www.jresdent.org/text.asp?2014/2/3/114/143594, Journal of Cutaneous and Aesthetic Surgery. Naik S, Hegde AM. Gruber C. The pharmacology of benzyl alcohol and its esters. BMC Oral Health 19, 3 (2019). The aim of this study was to evaluate and compare, both clinically and radiographically, the effects of calcium silicate-based materials (i.e., ProRoot MTA [PR-MTA], MTA-Plus [MTA-P], and Biodentine [BD]) and ferric sulfate [FS] in pulpotomy of primary molars.Materials and Methods. Restor Dent Endod. Huang TH, Ding SJ, Hsu TZ, Lee ZD, Kao CT. Root canal sealers induce cytotoxicity and necrosis. Pulp tissue reaction to formocresol and zinc oxide eugenol. Pediatr Dent 1983;59:6-8. Since the late 196O's a single-visit procedure for \atal primary molar pulpoto-mies has been … J Clin Pediatr Dent. As the split–mouth method was carried out, no difference between both groups (BiodentineTM and formocresol) concerning the patient’s age at the treatment time, gender and in the kind of molar treated was found. J Dent Res 1939;18:373-9. Ou Daigaku Shigakushi 1990;17:233-44. Myers DR, Pashley DH, Whitford GM, McKinney RV. Pulpotomy is the accepted therapy for the management of cariously exposed pulps in symptom-free primary molars; however, evidence is lacking about the most appropriate technique. Liu H, Zhou Q, Qin M. Mineral trioxide aggregate versus calcium hydroxide for pulpotomy in primary molars. Formocresol is a long–term clinically–successful medicament for use in the pulpotomy procedure, mostly due to its excellent clinical success and ease in use [ 2 ]. Int J Paediatr Dent 2002;12:177-82. J Pedod 1989;13:314-22. Table 1 shows the sample distribution of the evaluated teeth. J Dent Med Sci. It has the ability to create great participation in preserving the vitality of the pulp in children wisely chosen for pulpotomy procedure [7]. 2004;26:302–9. BiodentineTM was investigated in the current study because it was recently marketed and showed success in several clinical applications such as endodontic and restorative dentistry [8,9,10]. Agamy H, Bakry N, Mounir M, Avery D. Comparison of mineral trioxide aggregate and formocresol as pulp–capping agents in pulpotomized primary teeth. G–17–165–38) from the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. Formaldehyde-induced cytotoxicity and sister-chromatid exchanges in human lymphocyte cultures. Background: Formocresol, though the center of much controversy is still the most widely used medicament for primary teeth pulpotomy and an intracanal medicament which has undergone a lengthy evolution to shorten the formocresol application time and reduce the concentration of formocresol exposure to the pulp tissue. Terms and Conditions, Coggon D, Harris EC, Poole J, Palmer KT. PCO was observed in 10/56 cases (17.8%) in the BiodentineTM group, and in 7/56 cases (12.5%) in the formocresol group. Antibody formation to dog pulp tissue altered by formocresol within the root canal. Bakland LK. Article  Zealand C, Briskie D, Botero T, Boynton J, Hu J. Alexandria University; 1987. Markovic D, Zivojinovic V, Vucetic M. Evaluation of three pulpotomy medicaments in primary teeth. J Clin Pediatr Dent 2001;26:81-5. Pediatr Dent 1983;5:14-8. Correspondence to Both BiodentineTM and formocresol pulpotomy techniques demonstrated favorable clinical and radiographic outcomes in human primary molar teeth over a 12-month period without any significant difference. U.S. Environmental Protection Agency. In this meta‐analysis, the prognosis of pulpotomy in primary molars with formocresol versus ferric sulphate was evaluated clinically and radiographically. Boeve C, Dermaut L. Formocresol pulpotomy in primary molars: A long-term radiographic evaluation. The majority of the treated teeth were the lower second molar (44.6%), then the lower first molar (34%), upper second molar (16%), and upper first molar (5.4%). Is there life after Buckley's formocresol? Most read articles by the same author(s) Prachi Goyal, I K Pandit, Neeraj Gugnani, Monika Gupta, Neha Singla, Vikas Singla, CLINICAL EFFICACY OF VARIOUS MEDICAMENTS USED FOR PULPOTOMY IN PRIMARY MOLARS – A COMPARATIVE STUDY , International Journal of Research and Development in Pharmacy & Life Sciences: Vol. The reparative, biologic approach to pediatric pulp therapy is either devitalization approach of formocresol pulptomy or pulpectomy. Pross HF, Day JH, Clark RH, Lees RE. The current study has some advantages as it is one of the few recent randomized clinical trials using BiodentineTM for primary molars pulpotomy. Omar Abd El Sadek El Meligy. 2. J Endod 1987;13:500-5. Ranly DM. J Conserv Dent. Comparison of mineral trioxide aggregate and formocresol as pulp-capping agents in pulpotomized primary teeth. It was conducted to evaluate the success rate of BiodentineTM pulpotomy technique in human primary molars, clinically and radiographically and compare it with formocresol pulpotomy technique. Pulpotomy is conservative treatment performed to remove the inflamed coronal portion of the pulp by preserving the vitality of the remaining radicular pulp. 2012;34:120–8. The sample size was adequate. Group 2: Formocresol Pulpotomy. Electrosurgical pulpotomy in primates: A comparison with formocresol pulpotomy. This current randomized, split–mouth clinical study is considered as one of the few prospective clinical trials that used BiodentineTM in pulpotomy of primary molars in children. Caries control and other variables associated with success of primary molar vital pulp … This was performed by carrying out the block randomization technique with closed envelopes. Teeth were unselected if any of the previously–stated criteria were not met. Histological evaluation of electrosurgery and formocresol pulpotomy technique in primary teeth in dogs. An operator performed the pulpotomy procedures. 1 Departments of Conservative and Endodontics, Modern Dental College and Research Center, Indore, Madhya Pradesh, India2 Department of Pedodontics, Modern Dental College and Research Center, Indore, Madhya Pradesh, India, Correspondence Address:Shashidhar Chandrashekhar1663/56, 11th Main Road, Bank Colony, Siddaveerappa Extension, Davangere - 577 004, Karnataka IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI: 10.4103/2321-4619.143594 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('JRDS') + "&title=" + encodeURI ('Formocresol, still a controversial material for pulpotomy: A critical literature review') + "&publicationDate=" + encodeURI ('Sep 1 2014 12:00AM') + "&author=" + encodeURI ('Chandrashekhar S, Shashidhar J') + "&contentID=" + encodeURI ('JResDent_2014_2_3_114_143594') + "&orderBeanReset=true" Despite the new medicaments introduced for pulpotomy over the past years, formocresol pulpotomy still has popularity among paediatric dentists. Formaldehyde: Assessing the risk. Then the pulp chamber was washed with normal saline and bleeding was controlled by placing a cotton pellet moistened with water in the pulp chamber for 5 minutes. Purpose: The study evaluated the effects of 3 percent sodium hypochlorite (NaOCl) and formocresol (FC) as pulp dressing agents in pulpotomized primary molars. Federal-Provincial-Territorial Committee on Drinking Water. Ibricevic H, Heyeraas KJ, Pasic Juhas E, Hamamdzic M, Djordjevic N, Krnic J. PCO is a usual radiographic observation in pulpotomy procedures using formocresol, ferric sulfate, or BiodentineTM [1, 19, 34]. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Registered on NCT03779698. Its use in primary molars was not advocated until 1930 (3). While, formocresol requires a restorative material in the pulp chamber since it serves only as a pulpotomy medicament [32]. Inclusion and exclusion criteria were based on the following parameters. Scand J Dent Res 1977;85:583-7. Radiographically, the recruited teeth should have a normal radiographic appearance with healthy supporting tissues, no signs of internal resorption, or pathologic external root resorption and no periapical or inter–radicular pathosis, with at least two–thirds of the root remaining (not more than one–third of the root is physiologically resorbed). Preservation, the retention of maximum vital tissue with no … OAE Contributed to the design of the study, data analysis, results interpretation and in writing the manuscript. The improved properties of BiodentineTM, as well as its simple manipulation, may motivate dental practitioners to utilize this contemporary material as a practical choice in primary molars pulpotomy. Over the past 70 years, formocresol (FC) has been a popular medicament in the primary teeth, mainly because its easiness to use and the outcome of high clinical success rates. 2015;2015:359275. Available from: www.iarc.fr/ENG/Press_Releases/archives/pr153a.html [Last accessed on 2006 Mar 13]. Two … J Res Med Sci 2004;6:304-7. Consolidated Standards of Reporting Trials. Outcomes of vital pulp therapy using mineral trioxide aggregate or BiodentineTM: a prospective randomized clinical trial. Efficacy of three different pulpotomy agents in primary molars: a randomized control trial. Int Endod J 1991;24:279-89. Srinivasan V, Patchett CL, Waterhouse PJ. J Mater Sci Mater Med 2004;15:767-71. Shashidhar Chandrashekhar1, Jyothi Shashidhar2 Clinical Procedure . Awawdeh L, Al-Qudah A, Hamouri H, Chakra RJ. Schroder U. El-Meligy O, Abdalla M, El-Baraway S, El-Tekya M, Dean JA. Ranly DM, García-Godoy F. Reviewing pulp treatment for primary teeth. This increased success rate of formocresol in the current research is attributed to the precise criteria used for teeth selection and to the antiseptic (germicidal) and fixative properties of formocresol. Eur Arch Paediatr Dent. Current concepts in vital pulp therapy. Int Endod J 1997;30:175-80. Tissue changes induced by the absorption of formocresol from pulpotomy sites in dogs. J Dent Child. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None. Regarding radiographical calibration, inter–examiner (k=0.97) and intra–examiner agreement (k=0.98 and 0.97 for the 2 examiners) was also considered excellent. Ribeiro DA, Scolastici C, De Lima PL, Marques ME, Salvadori DM. Fuks AB, Bimstein E, Guelmann M, Klein H. Assessment of a 2 percent buffered glutaraldehyde solution in pulpotomized primary teeth of school children. Results: 9 Articles were selected for the systematic review. BiodentineTM drew awareness in the specialty of endodontics due to its excellent sealing ability, handling properties, biocompatibility, stability, long–term impermeability, low solubility, quick setting time, and capability to induce hard tissue regeneration. In control (group II), a sterile cotton pellet moistened with 1:5 concentration formocresol (Buckley’s Formocresol, Sultan Healthcare, Englewood, NJ, USA) then blotted to remove excess was placed for 5 minutes on the pulp stumps and then the pulps were covered with zinc oxide–eugenol (IRM; Dentsply, Milford, DE) dressing. Each patient had at least 2 matched bilateral carious primary molars requiring pulpotomy. NMA Participated in planning of the research, literature search and critically reviewing the manuscript. J Res Med Sci. At 12 months, the clinical success rates of both BiodentineTM and formocresol groups were 100%, while the radiographic success rates for BiodentineTM and formocresol groups were 100% and 98.1%, respectively. The clinical and radiographic success of primary molar pulpotomy using Biodentine™ and mineral trioxide aggregate: a 24-month randomized clinical trial. An investigation of the relative efficacy of Buckley's Formocresol and calcium hydroxide in primary molar vital pulp therapy. Ibricevic H, Al-Jame Q. Ferric sulfate as pulpotomy agent in primary teeth: Twenty month clinical follow-up. Shulman ER, McIver FT, Burkes EJ Jr. Available from: http://www.oecd.org/dataoecd/24/22/31744923.pdf [Last accessed on 2007 Mar 13]. Generally, lower molars (79%) were more frequently recruited than upper ones (21%). Ibricevic H, Al-Jame Q. Ferric sulphate and formocresol in pulpotomy of primary molars: Long term follow up study. In some cases an adult tooth might have decay down to the pulp but the pulp is still pretty healthy. Effects of selected inflammatory mediators in blood flow and vascular permeability in the dental pulp. Background: Formocresol remains to be the preferred medicament in pulpotomy, despite the concerns regarding tissue devitalization and systemic toxicity. Chin J Dent Res 2011;14:121-5. statement and PubMed  Sopot, Poland: 12th congress of EAPD; 2014. Bhatt HS, Lober SB, Combes B. Allergy 2003;58:668-71. Although the number of participants was sufficient, it is premature to draw a final conclusion, because of the short follow–up period. Formocresol, first introduced by Buckley in 1904, as a pulpotomy medicament 1 has long been considered the “gold standard” to which all other medicaments are compared for primary tooth pulpotomy. Pashley EL, Myers DR, Pashley DH, Whitford GM. Pediatr Dent 2000;22(4):278-86. BMC Oral Health The pulpotomy agents were ass… 2017;18:271–8. Environ Sci Technol 1984;18:216-21a. Pulpotomy entails the removal of infected coronal pulp followed by placement of a suitable medicament to preserve the health of remaining radicular pulp. Agreement between clinical and histologic findings in chronic coronal pulpitis in primary teeth. J Dent Child 1985;52:4331-4. Proc Finn Dent Soc 1992;88 Suppl 1:393-401. Various in vitro and in vivo researches have confirmed the bioactivity of BiodentineTM, also its outstanding performance in vital pulp treatment [12,13,14]. I 2004;6:55–8. J Endod. treated with formocresol as a pulpotomy medicament and Group B was treated with diode laser as a pulpotomy technique. Comparing gray mineral trioxide aggregate and diluted formocresol in pulpotomized human primary molars. Fei AL, Udin RD, Johnson R. A clinical study of ferric sulfate as a pulpotomy agent in primary teeth. The most common materials used for pulpotomy are formocresol, ferric sulfate, also calcium hydroxide has been used, but with less long term success and more recently mineral trioxide aggregate (MTA) which is much more expensive 8,10. Formocresol concentration • It is therefore recommended that 1/5th concentration formocresol be utilized for pulpotomy procedure since it is as effective as and less damging than the traditional preparation. Preoperative periapical radiographs of the molars considered for treatment were taken using the XCP extension cone paralleling technique. The pulpotomized tooth was judged to be radiographically successful if it demonstrated the following criteria [1,18,19,22, 1) Normal periodontal ligament space (2) No periapical and furcation pathosis, and (3) No internal resorption. The level of significance was set at P < 0.05. J Tenn Dent Assoc 2009;89:14-7. 2012;34(7):e202-e208. Within a … Effects of formaldehyde in the rat and dog following oral exposure. Yoldaş SE, Bani M, Atabek D, Bodur H. Comparison of the potential discoloration effect of Bioaggregate, BiodentineTM, and white mineral trioxide aggregate on bovine teeth: in vitro research. Since the teeth indicated for pulpotomy must be treated as soon as possible, the patients were included at the time of diagnosis (identification) and randomization for the materials on the sides was done. A fresh look at the evidence concerning safety issues. Also, formocresol is used for pulpotomies of primary teeth in Pediatric Dental Clinics, Faculty of Dentistry, KAU, Jeddah. Rolling I, Thulin H. Allergy tests against formaldehyde, cresol, and eugenol in children with pulpotomized primary teeth. Sakai V, Moretti A, Oliviera T, et al. Pediatr Dent 1986;8:16-21. PCO was observed in 10 (17.8%) molars in the BiodentineTM group and just 7 (12.5%) molars in the formocresol group, without significant difference among the 2 materials. The present result of 17.9% for PCO in the BiodentineTM technique was in the range observed as in MTA [1, 19, 22, 37]. Nowicka A, Lipski M, Parafiniuk M, Sporniak–Tutak K, Lichota D, Kosierkiewicz A, Kaczmarek W, Buczkowska–Radlińska J. All the teeth received stainless steel crown after … Pulp canal obliteration was radiographically observed in 10/56 (17.9%) and 7/56 (12.5%) cases in the BiodentineTM and formocresol groups, respectively. Spedding RH, Mitchell DF, McDonald RE. 2018;44:1603–9. This study was carried out on healthy children aged 4– to 8–year–old. The radiographic and clinical evaluation of treatment outcomes was performed at 12 and 24 months post-operatively. The effects of laser irradiation on the activation of inflammatory cells and the vital pulpotomy. Authors Miguel-Angel Simancas-Pallares 1 , … The National Institute for Occupational Safety and Health (NIOSH) Formaldehyde. IARC classifies formaldehyde as carcinogenic to humans: Press release no. Oral Surg Oral Med Oral Pathol 1978;45:282-92. Myers DR, Shoaf HK, Dirksen TR, Pashley DH, Whitford GM, Reynolds KE. J Am Dent Assoc 1978;96:805-13. Effects of calcium hydroxide-containing pulp-capping agents on pulp cell migration, proliferation, and differentiation. 2000;28:855–8. Selection of the method used in vital pulp therapy relies on the degree of inflammation of the pulp. [1] Doyle et al. Box 1666, AlRass, 51921, Qassim, Kingdom of Saudi Arabia, You can also search for this author in Tissue lead levels in dogs with RC-2B root canal fillings. J Periodontol. Springer Nature. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. 2010 Nov 1;15(6):e942-6. Mineral trioxide aggregate vs. formocresol in pulpotomized primary molars: A preliminary report. Pediatr Dent. Sample size calculation for binary outcome equivalence trials was calculated using sample size calculators of a sealed envelope, randomization and online databases for clinical trials at https://www.sealedenvelope.com/power/binary-equivalence/. 029–14). Pulpotomy therapy in primary teeth: New modalities for old rationales. Int Endod J. In addition to the findings of clinical follow--radiographic and taking into account the potential toxicity of formocresol suggest the use of mineral trioxide aggregate pulpotomy of primary tee … Mineral trioxide aggregate in primary teeth pulpotomy. Formocresol was introduced to treat non-vital permanent teeth in the United States by Buckley in 1904. J Calif Dent Assoc. Devitalization, where the intent is to destroy vital tissue, is typified by formocresol and electrocautery. Study design: A total of 100 incisors in 50 patients (female: 27, male: 23)aged 3-4 years were allocated to formocresol pulpotomy (45 teeth) and RCT (46 teeth) using zinc oxideeugenol. Pulpotomy of human primary molars … Initially, the technique involved five visits. J Am Dent Assoc. All authors read and approved the final manuscript. Figure 2 shows radiographs of one successfully treated tooth for each of the 2 study groups. 2011;2(4):296-301. J Endod. Cookies policy. Seow WK, Thong YH. Pediatr Dent 1999;21:327-31. https://www.sealedenvelope.com/power/binary-equivalence/, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s12903-018-0702-4. ASDC J Dent Child 1965;32:13-28. 54 Pulpotomy techniques using formocresol on primary teeth have been a standard in pediatric dentistry for decades. Immunologic studies of subjects with asthma exposed to formaldehyde and urea-formaldehyde foam insulation (UFFI) off products. Formocresol is a long–term clinically–successful medicament for use in the pulpotomy procedure, mostly due to its excellent clinical success and ease in use [2]. Neamatollahi H, Tajik A. Google Scholar. Waterhouse PJ, Nunn JH, Whitworth JM. The pulpotomy procedure was decided a clinical success if the tooth fulfilled the following criteria [1, 18, 19, 22]: (1) No pain, (2) No swelling, (3) No tenderness to percussion, (4) No abscess or fistula, and (5) No abnormal tooth mobility. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99:637-40. Inter– and intra–examiner agreement was performed using the Kappa statistic. 2017;39:16–123. Study design: A total of 100 incisors in 50 patients (female: 27, male: 23) aged 3-4 years were allocated to formocresol pulpotomy (45 teeth) and RCT (46 teeth) using zinc oxideeugenol. Jukiæ S, Aniæ I, Koba K, Najzar-Fleger D, Matsumoto K. The effect of pulpotomy using CO2 and Nd: YAG lasers on dental pulp tissue. Eidelman E, Holan G, Fuks AB. Genotoxicity of antimicrobial endodontic compounds by single cell gel (comet) assay in Chinese hamster ovary (CHO) cells. This research received a grant (no. Crosby RM, Richardson KK, Craft TR, Benforad KB, Liber HL, Skopek TR. Kopel HM, Bernick S, Zachrisson E, DeRomero SA. Rajasekharan S, Martens LC, Vandenbulcke J, Jacquet W, Bottenberg P, Cauwels RG. ASDC J Dent Child 1980;47:425-30. An enzyme histochemical study of the effect of various concentrations of formocresol on connective tissues. 19. No statistically significant differences were recorded between any of the groups at 3, 6, and 12 months. Pulpotomy therapy for the primary dentition has developed along three lines: devitalization, preservation, and regeneration. Reaction of the pulp to calcium hydroxide. 2 Despite years of apparent successful use as a pulpotomy agent, it has become necessary to study and document formocresol because of its toxic, mutagenic and carcinogenic properties. Pulp therapy for primary and immature permanent teeth. The obsolescence of formocresol. Pediatr Dent 1991;13:327-32. IARC Monogr Eval Carcinog Risks Hum 1995;62:217-375. Jabbarifar SE, Khademi AA, Ghasemi D. Success rate of formocresol pulpotomy versus mineral trioxide aggregate in human primary molar tooth. An analysis of potential carcinogenic risk from formaldehyde Regul Toxicol Pharmacol 1984;4:107-29. Acta Odontol Pediatr 1984;5:93-8. Assessment of the systemic distribution and toxicity of formaldehyde following pulpotomy treatment: Part one. Lewis B. In: Duggal MS, editor. Results of the current research revealed high clinical and radiographic success rates at all observation periods for the 2 medicaments used; this might be due to correct protocol, complete isolation and tooth selection, good aseptic conditions, and appropriate manipulation for the material. 2012;38:1220–6. Privacy Part of This project was funded by the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia under grant no. The alternatives to formocresol are discussed and their advantages and disadvantages are evaluated. American Academy of Pediatric Dentistry. Vij R, Coll JA, Shelton P, Farooq NS. Mutat Res 1983;120:51-5. Controversies surrounding formocresol which enjoys good clinical success as a pulpotomy medicament has triggered the search for better alternatives. Holan G, Eidelman E, Fuks A. Long–term evaluation of pulpotomy in primary molars using mineral trioxide aggregate or formocresol. The children were selected from the Pediatric Dentistry Clinics, Faculty of Dentistry, King Abdulaziz University (KAU), Jeddah. Comparative study of antimicrobial activity of "BiodentineTM " and "Rootdent" cements and "Futurabond NR" adhesive. Available from: www.hc-sc.gc.ca/ewh-semt/pubs/water-eau/doc_sup-appui/index_e.html [Last on accessed 2006 Mar 13]. 1 [21]. Dummett CO Jr, Kopel HM. Eur J Pediatr Dent 2002;3(3):115-20. Erdem A, Guven Y, Balli B, Ilhan B, Sepet E, Ulukapi I, Aktoren O. They were also similar to a recent study, which found clinical and radiographic success rates of 95.24% and 94.4% respectively for this novel material, but with a longer follow–up period and a smaller sample size [37]. Eur J Paediatr Dent. One patient with 4 (3.6%) pulpotomized teeth (2 pairs) was unavailable for the 12–month evaluation. Organization for Economic Development and Cooperation, Screening Information Data Set, Initial Assessment Profile. The prevalence of IgE sensitization to formaldehyde in asthmatic children. One tooth from each pair was randomly assigned to either the BiodentineTM pulpotomy group or the formocresol pulpotomy group. 2013;92:37–9. Miller M, Truhe T. Lasers in dentistry: An overview. Part I – a narrative review of alternative interventions and materials. In the experimental group (group I), BiodentineTM (Septodont Ltd., Saint Maur des Faussés, France) was used following the manufacturer’s recommendations. Formocresol and calcium hydroxide therapy. Pediatr Dent. 2011;9:672–7. … Shaw DW, Sheller B, Barrus BD, Morton TH Jr. Electrosurgical pulpotomy--A 6-month study in primates. Schroder U. The BiodentineTM group had a radiographic success rate of 100% at 6 and 12–month follow–up periods, while the formocresol group had a radiographic success rate of 100% at 6 months, followed by 98.1% at 12 months (Table 2). Formocresol pulpotomy has remained a treatment of choice in primary teeth and is widely accepted1. 2017;39:325–33. Modulation of polymorphonuclear leukocyte adherence by pulpotomy medicaments: Effects of formocresol, glutaraldehyde, eugenol, and calcium hydroxide. Fuks AB. Therefore, BiodentineTM could a good replacement to the current medicaments for regeneration of dentin–pulp complex [7]. Heck H, Casanova M. Pharmacodynamics of formaldehyde: Applications of a model for the arrest of DNA replication by DNA-protein cross-links. J Natl Cancer Inst 2003;95:1608-15. The authors, therefore, acknowledge with thanks DSR for technical and financial support. J Dent Res 1965;44:1023-34. Available from: http://www.inchem.org/documents/ehc/ehc/ehc89.htm [Last accessed on 2007 Mar 13]. J Clin Pediatr Dent 2000;24:269-72. J Res Dent. In: Ingle J, Bakland L, editors.