Poor outcome in patients was associated with more pronounced cortical thinning. The high-inflammation group had significantly greater cortical thinning than the low-inflammation group in four Main Outcome Measures Cortical thickness and change in cortical thickness on a vertex-by-vertex basis across the cortical mantle, measures of functional and symptomatic outcome, and cumulative intake of antipsychotics during the scan interval. cortical thickness at every voxel of each hemisphere with a conservative threshold of Po.01.2 Regional clusters in which cortical thickness differed according to level of in-flammation were identified and examined independently. Over time, excessive cortical thinning was found in widespread areas on the cortical mantle, most pronounced bilaterally in the temporal cortex and in the left frontal area. Impulsive personality traits are often predictive of risky behavior, but not much is known about the neurobiological basis of this relationship. Global thinning was apparent by middle age. adj., adj cor´tical. cortex [kor´teks] (pl. Cortical thickness was estimated as the distance between the gray/white boundary and the outer cortical surface, resulting in a continuous estimate across the cortical mantle. Men and women showed a similar degree of global thinning, and did not differ in mean thickness in the younger or older groups. In a sample of twins ( n = 1113), we determined structural covariance of thickness to be organized along both a posterior-to-anterior and an inferior-to-superior axis. The assumed model also has some analogy with reality [1], where the cortical mantle is divided into 6 laminal layers. cor´tices) (L.) the outer layer of an organ or other structure, as distinguished from its inner substance or medulla. The topology of the cerebral cortex has been proposed to provide an important source of constraint for the organization of cognition. We investigated whether thickness of the cortical mantle varied as a function of impulsive traits and whether such variation also explained recent risky behavior. Regardless of the algorithms used to detect the surfaces and calculate thickness, it is necessary to segment the Estimates of cortical thickness at 81,924 vertices covering the entire cortical mantle were regressed on attentional absorption scores across the whole sample. adrenal cortex (cortex of adrenal gland) the outer, firm layer comprising the larger part of the adrenal gland; it secretes mineralocorticoids, androgens, and glucocorticoids. 3). Mean cortical thickness did not differ between the groups. 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